Water-Dispersible and Biocompatible Iron Carbide Nanoparticles with High Specific Absorption Rate

Alexis Bordet (1) , Ryan F Landis (2) , Yiwei Lee (2) , Gulen y Tonga (2) , Juan Manuel Asensio (1) , Chenghsuan Li (2) , Pier-Francesco Fazzini (1) , Aikaterini Soulantika (1) , Vincent M. Rotello (2) , Bruno Chaudret (1)

1 LPCNO - Laboratoire de physique et chimie des nano-objets
2 Department of Chemistry [Amherst]

Magnetic nanoparticles are important tools for biomedicine, where they serve as versatile multifunctional instruments for a wide range of applications. Among these applications, magnetic hyperthermia is of special interest for the destruction of tumors and triggering of drug delivery. However, many applications of magnetic nanoparticles require high quality magnetic nanoparticles displaying high specific absorption rates, which remains a challenge today. We report here the functionalization and stabilization in aqueous media of highly magnetic 15 nm iron carbide nanoparticles featuring excellent heating power through magnetic induction. The challenge of achieving water solubility and colloidal stability was addressed by designing and using specific dopamine-based ligands. The resulting nanoparticles were completely stable for several months in water, phosphate, phosphate-buffered saline and serum-containing media. Iron carbide nanoparticles displayed high specific absorption rates (SAR) in water and viscous media (water/glycerol mixtures), even after extended exposition to water and oxygen (SAR up to. 1000 W·g-1 in water at 100 kHz, 47 mT). The cytotoxicity and

Domaines: Chimie; Chimie inorganique; Chimie thérapeutique; Matériaux

Alexis Bordet, Ryan F Landis, Yiwei Lee, Gulen y Tonga, Juan Manuel Asensio, et al.. Water-Dispersible and Biocompatible Iron Carbide Nanoparticles with High Specific Absorption Rate. ACS Nano, In press. ⟨hal-02051157⟩