A shear-induced network of aligned wormlike micelles in a sugar-based molecular gel. From gelation to biocompatibility assays

Juliette Fitremann (1, 2) , Barbara Lonetti (1, 2) , Emiliano Fratini , Isabelle Fabing (3) , Bruno Payre (4) , Christelle Boulé , Isabelle Loubinoux (5) , Laurence Vaysse (5) , Luis Oriol

1 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
2 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables
3 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique
4 CMEAB - Centre de Microscopie Électronique Appliquée à la Biologie
5 ToNIC - Toulouse NeuroImaging Center

gels showed thixotropic behaviour, recovering slowly their initial elastic modulus, in few hours, after injection through a needle. Stable gels were tested as scaffold for neural cell line culture, showing a reduced biocompatibility. This new gelator is a clear illustration of how controlling the pathway was critical for gel formation and how a new kind of self-assembly was obtained by shearing.

Mots clés: supramolecular; gel; self-assembly; carbohydrate amphiphile; saccharide; triazole; fiber; fibre; cylindrical micelle; shear; cell culture; biomaterial; LMWG; low molecular weight gelator. Electronic Supplementary Information: Experimental section; extra electronic microscopy data; HLPC-MS chromatograms; NMR spectra

Domaines: Chimie

Juliette Fitremann, Barbara Lonetti, Emiliano Fratini, Isabelle Fabing, Bruno Payre, et al.. A shear-induced network of aligned wormlike micelles in a sugar-based molecular gel. From gelation to biocompatibility assays. Journal of Colloid and Interface Science, 2017, 504, pp.721-730. ⟨10.1016/j.jcis.2017.06.021⟩. ⟨hal-02060389⟩