Selective N-methylation of ethyl esters of 3-(1H-imidazol-4-yl)-2-propenoic acid

Hiba Mawlawi (1) , Marie-Carmen Monje (1) , Armand Lattes (1) , M. Rivère (1)

1 IMRCP - Interactions moléculaires et réactivité chimique et photochimique

Methods of selective methylation of the nitrogen atoms of the ethyl ester of 3‐(1H‐imidazol‐4‐yl)‐2‐propenoic acid are reported. The nitrogen atom α to the ethylenic chain was methylated after protection of the β nitrogen with a phenacyl group.

Mots clés: Methylation; Propenoic acid

Domaines: Chimie organique

Hiba Mawlawi, Marie-Carmen Monje, Armand Lattes, M. Rivère. Selective N-methylation of ethyl esters of 3-(1H-imidazol-4-yl)-2-propenoic acid. Journal of Heterocyclic Chemistry, 1992, 29 (6), pp.1621-1624. ⟨10.1002/jhet.5570290643⟩. ⟨hal-02067313⟩