Extended photo-induced endosome-like structures in giant vesicles promoted by block-copolymer nanocarriers

C. Montis (1) , Ugo Till (2, 3, 4) , P. Vicendo (2, 4) , Anne-Françoise Mingotaud (2, 4) , Frédéric Violleau (3) , Clément Roux (2, 4) , Maxime Demazeau (2, 4) , D. Berti (1) , Barbara Lonetti (2, 4)

1 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
2 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
3 CAI - Chimie Agro-Industrielle
4 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables

Upon irradiation, the photosensitizer pheophorbide a causes dramatic morphological transitions in giant unilamellar lipid vesicles. The endocytosis-like process occurs only when the photoactive specie is encapsulated in a copolymer nanocarrier and strictly depend on the chemical nature of the copolymer. Altogether, these results open up new perspectives in the field of photo-chemical internalization mediated by nanoassemblies.

Domaines: Polymères; Chimie théorique et/ou physique

C. Montis, Ugo Till, P. Vicendo, Anne-Françoise Mingotaud, Frédéric Violleau, et al.. Extended photo-induced endosome-like structures in giant vesicles promoted by block-copolymer nanocarriers. Nanoscale, 2018, 10 (33), pp.15442-15446. ⟨10.1039/C8NR04355H⟩. ⟨hal-02171159⟩