Smart metallopoly(l-glutamic acid) polymers: Reversible helix-to-coil transition at neutral pH

Colin V. Bonduelle (1) , Fatma Makni (1) , Laura Severac (1) , Estefanía Piedra-Arroni (1) , Charles Louis Serpentini (2, 3) , Sébastien Lecommandoux (4, 5) , Geneviève Pratviel (1)

1 LCC - Laboratoire de chimie de coordination
2 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
3 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables
4 LCPO - Laboratoire de Chimie des Polymères Organiques
5 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Among the smart polymers, smart polypeptides have a unique polymeric scaffold made of amino acids whose structuring can be controlled by an external stimuli. Herein we present how coordination chemistry to Zn species can be reversibly used to control the helix-to-coil transition of synthetic poly(l-glutamic acid) (PGA) polymers at a neutral pH of 7 in aqueous solutions.

Mots clés: Amino acids; Coordination reactions; Scaffolds (biology); Solutions; Co-ordination chemistries; External stimulus; Helix-to-coil transitions; L-glutamic acids; Neutral pH; Poly-(L-glutamic acid); Polymeric scaffold; Smart polymers; Polymers

Domaines: Polymères

Colin V. Bonduelle, Fatma Makni, Laura Severac, Estefanía Piedra-Arroni, Charles Louis Serpentini, et al.. Smart metallopoly(l-glutamic acid) polymers: Reversible helix-to-coil transition at neutral pH. RSC Advances, 2016, 6 (88), pp.84694-84697. ⟨10.1039/c6ra19753a⟩. ⟨hal-01372525⟩