Assembly of Double-Hydrophilic Block Copolymers Triggered by Gadolinium Ions: New Colloidal MRI Contrast Agents

Camille Frangville (1) , Yichen Li (2) , Claire Billotey (3) , Daniel R. Talham (4) , Jacqueline Taleb (5) , Patrick Roux (6) , Jean-Daniel Marty (1, 7) , Christophe Mingotaud (1, 7)

1 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
2 LAL - Laboratoire de l'Accélérateur Linéaire
3 EA3738 - Ciblage thérapeutique en Oncologie
4 UF - University of Florida [Gainesville]
5 CREATIS - Centre de Recherche et d'Application en Traitement de l'Image et du Signal
6 IRSN/DPAM/SEMCA/LESAG - Laboratoire d'Etudes et de Simulation des Accidents Graves
7 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables

Mixing double-hydrophilic block copolymers containing a poly(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range of pH and ionic strength. High magnetic relaxivities were measured in vitro for these biocompatible colloids, and in vivo magnetic resonance imaging on rats demonstrates the potential utility of such polymeric assemblies.

Mots clés: gadolinium; Magnetic Resonance Imaging; nanoparticle; MRI; micelle; block copolymer; Polymer

Domaines: Polymères; Chimie; Science des matériaux [cond-mat.mtrl-sci]

Camille Frangville, Yichen Li, Claire Billotey, Daniel R. Talham, Jacqueline Taleb, et al.. Assembly of Double-Hydrophilic Block Copolymers Triggered by Gadolinium Ions: New Colloidal MRI Contrast Agents. Nano Letters, 2016, 16 (7), pp.4069-4073. ⟨10.1021/acs.nanolett.6b00664⟩. ⟨hal-02195760⟩