Cell polarity and actin mRNA localization

B. Lavoie , E. Basyuk (1) , R. Bordonne (2) , Edouard Bertrand (3)

1 IBDM - Institut de Biologie du Développement de Marseille
2 IGMM - Institut de Génétique Moléculaire de Montpellier
3 LBME - Laboratoire de biologie moléculaire eucaryote

In many species, intracellular mRNA localization is linked to cell polarity. In many cases however, mRNAs become localized as a result of a pre-existing cell-polarity, and they do not modify it. Remarkably, in the case beta actin mRNA in vertebrate, it has been shown that the transport and localization of this RNA is required for the establishment and maintenance of cell polarity. This occurs in fibroblasts, but, very interestingly, in immature neurons as well. This review will describe the functions and mechanisms of actin mRNA localization.

Mots clés: in-situ hybridization binding protein intracellular-localization growth cones neurons motility oligodendrocytes microfilaments translation fibroblasts

Domaines: Biochimie, Biologie Moléculaire

B. Lavoie, E. Basyuk, R. Bordonne, Edouard Bertrand. Cell polarity and actin mRNA localization. Médecine/Sciences, 2004, 20 (5), pp.539--543. ⟨10.1051/medsci/2004205539⟩. ⟨hal-02262413⟩