Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy

Amandine Oudin (1, 2) , Julie Chauvin (1, 3) , Laure Gibot (4, 1, 3) , Marie-Pierre Rols (4) , Stephanie Balor (5) , Dominique Goudounèche (6) , Bruno Payre (6) , Barbara Lonetti (1, 3) , Patricia Vicendo (1, 3) , Anne-Françoise Mingotaud (1, 3) , Vincent Lapinte (2)

1 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
2 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
3 IMRCP - IDeAS - IMRCP - Interfaces Dynamiques et Assemblages Stimulables
4 IPBS - Institut de pharmacologie et de biologie structurale
5 CBI - Centre de Biologie Intégrative
6 CMEAB - Centre de Microscopie Électronique Appliquée à la Biologie

An amphiphilic polymer (CmPOX) based on poly(2-methyl-2-oxazoline) linked to a hydrophobic part composed of an aliphatic chain ended by a photo-active coumarin group has been synthesized. It exhibits the ability of forming small polymeric self-assemblies, typically of ca. 10 nm in size which were characterized by TEM, cryo-TEM and DLS. The nanocarriers were further formulated to yield photo-crosslinked systems by dimerization of coumarin units of a coumarinfunctionalized poly(methyl methacrylate) (CmPMMA) and CmPOX. The formed vectors were used to encapsulate Pheophorbide a, a known photosensitizer for PhotoDynamic Therapy. Cytotoxicity as well as photooxicity experiments led in vitro on human tumor cells revealed the great potential of these nanovectors for photodynamic therapy.

Domaines: Polymères; Pharmacie galénique

Amandine Oudin, Julie Chauvin, Laure Gibot, Marie-Pierre Rols, Stephanie Balor, et al.. Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy. Journal of materials chemistry‎ B, 2019, 7 (32), pp.4973-4982. ⟨10.1039/c9tb00118b⟩. ⟨hal-02276059⟩