Chemically modified polysulfones for molecular imprinting. Synthesis and complexation with a fluorescent model template

Nasreddine Kébir (1) , Nathalie Sabathié (1) , Clara Fournier-Nöel (1) , Suzanne Fery-Forgues (1) , Jean-Francois Lahitte (2) , Jean-Christophe Remigy (2)

1 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
2 LGC - Laboratoire de Génie Chimique

Polysulfone (PSU) was chemically modified to prepare new molecular imprinted membranes (MIMs). Several amounts of amine and sulfonyl groups were introduced into the PSU chemical structure in order to create interactions with acid or base templates, such as biomolecules or biomacromolecules. A fluorescent dye, Acridine Orange base (AO), was used as a model template and its complexation with the prepared PSUs was monitored by spectroscopic techniques. This study showed an absence of complexation with the native PSU and a strong complexation with the aminated and the sulfonated PSUs. Partially allylated PSU bearing amine or sulfonyl groups were also synthesized. These compounds are expected to be used as precursors for designing new crosslinked molecular imprinting membranes (MIMs), exhibiting high stability of the template memory.

Mots clés: Polysulfone; Molecular imprinting; MIP; MIM

Domaines: Polymères

Nasreddine Kébir, Nathalie Sabathié, Clara Fournier-Nöel, Suzanne Fery-Forgues, Jean-Francois Lahitte, et al.. Chemically modified polysulfones for molecular imprinting. Synthesis and complexation with a fluorescent model template. Reactive and Functional Polymers, 2013, vol. 73 (3), pp. 531-539. ⟨10.1016/j.reactfunctpolym.2012.12.003⟩. ⟨hal-00875893⟩