Nitric oxide photo-release from a ruthenium nitrosyl complex with a 4,4'-bisfluorenyl-2,2'-bipyridine ligand

Max Roose (1, 2) , Isabelle Sasaki (1) , Valerii Bukhanko (1, 2) , Sonia Mallet-Ladeira (1, 3) , Rodrigo M. Barba-Barba (4) , Gabriel Ramos-Ortiz (4) , Alejandro Enriquez-Cabrera (5) , N. Farfan (5) , Pascal G. Lacroix (1) , Isabelle Malfant (1, 2)

1 LCC - Laboratoire de chimie de coordination
2 UT3 - Université Toulouse III - Paul Sabatier
3 ICT - Institut de Chimie de Toulouse
4 CIO - Centro de Investigaciones en Optica
5 Facultad de Quimica, Universidad Nacional Autonoma de Mexico

A ruthenium nitrosyl complex of formula [RuII(terpy)(F2B)(NO)](PF6)3, where terpy stands for 2,2′:6′,2″-terpyridine and F2B for 4,4′-bis(9,9′-dibutyl-9H-fluoren-2-yl)-2,2′-bipyridine, is presented and fully characterized. The X-ray crystal structure of F2B is reported. The electronic properties of the complex are compared to those of related [RuII(terpy)(bpy)(NO)]3+ complexes having a bipyridine (bpy) free of fluorene or bearing a fluorene on the terpyridine ligand. DFT computations are provided to support the experimental data. [RuII(terpy)(F2B)(NO)](PF6)3 releases NO under irradiation at 405 nm with a quantum yield (ϕNO) equal to 0.033. Additionally, the two-photon absorption cross-section investigated at 800 nm by the Z-scan technics is equal to 156 ± 23 GM, which indicates that the complex can release NO under irradiation in the therapeutic window.

Domaines: Chimie de coordination

Max Roose, Isabelle Sasaki, Valerii Bukhanko, Sonia Mallet-Ladeira, Rodrigo M. Barba-Barba, et al.. Nitric oxide photo-release from a ruthenium nitrosyl complex with a 4,4'-bisfluorenyl-2,2'-bipyridine ligand. Polyhedron, 2018, 151, pp.100-111. ⟨10.1016/j.poly.2018.05.028⟩. ⟨hal-01961813⟩