Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

Vincent Minville (1) , Lionel Moulédous (2) , Acil Jaafar (3) , Réjean Couture (4) , Anne Brouchet (5) , Bernard Frances (6) , Ivan Tack (3) , Jean-Pierre Girolami (3)

1 Pôle Anesthésie Réanimation [CHU de Toulouse]
2 IPBS - Institut de pharmacologie et de biologie structurale
3 I2MR - Institut de médecine moléculaire de Rangueil
4 Département de Physiologie
5 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
6 CRCA - Centre de Recherches sur la Cognition Animale - UMR5169

Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain.

Mots clés: Pain; Orthopedic; Analgesia; B1 receptor; B2 receptor; Bradykinin; Fracture

Domaines: Sciences du Vivant [q-bio]; Pharmacologie

Vincent Minville, Lionel Moulédous, Acil Jaafar, Réjean Couture, Anne Brouchet, et al.. Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists. Journal of Translational Medicine, 2019, 17 (1), pp.346. ⟨10.1186/s12967-019-2095-9⟩. ⟨hal-02352015⟩