A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1

Christel Cinq-Frais (1) , Christelle Coatrieux (1) , Marie-Hélène Grazide (2) , Yusuf A. Hannun (3) , Anne Nègre-Salvayre (4) , Robert Salvayre (4) , Nathalie Augé (4)

1 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
2 I2MR - Institut de médecine moléculaire de Rangueil
3 SBU - Stony Brook University [SUNY]
4 Régulations cellulaires: lipidoses et atherosclerose

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Christel Cinq-Frais, Christelle Coatrieux, Marie-Hélène Grazide, Yusuf A. Hannun, Anne Nègre-Salvayre, et al.. A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2013, 1831 (8), pp.1344-1356. ⟨10.1016/j.bbalip.2013.04.014⟩. ⟨hal-02352434⟩