Ibuprofen loading into Mesoporous Silica Nanoparticles using Co- Spray Drying : a Multi-Scale Study

Lucas Ruffel (1) , Jeremy Soulié (2) , Yannick Coppel (3) , Pierre Roblin (1) , Fabien Brouillet (2) , Christine Frances (1) , Mallorie Tourbin (1)

1 LGC - Laboratoire de Génie Chimique
2 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux
3 LCC - Laboratoire de chimie de coordination

Mesoporous Silica Nanoparticles (MSN) are used in an increasing number of applications in nanomedicine. Their synthesis and external/internal functionalization have been extensively studied as well as their biological properties. Nevertheless, the conventional drug loading processes of MSN (such as impregnation), do not enable sufficient efficiency and are difficult to consider on an industrial scale. To overcome these limitations, we implemented an innovative co-spray-drying process, using a nano spray-dryer, to load MSN with ibuprofen molecules. In this contribution, complementary techniques were used to perform a multi-scale characterization of the loaded particles. Spray-dried powders have been analysed from aggregates size and morphology to pore loading and ibuprofen conformation. This study demonstrates that ibuprofen/silica weight ratio in the initial suspension strongly affects the location (into 2 mesopores or external) and the conformation (crystallized, amorphous or liquid-like) of ibuprofen. The quantification of each phase has allowed calculating precise loading rates and demonstrate tunable pore filling.

Mots clés: Mesoporous silica nanoparticles; drug loading; spray-drying

Domaines: Génie des procédés

Lucas Ruffel, Jeremy Soulié, Yannick Coppel, Pierre Roblin, Fabien Brouillet, et al.. Ibuprofen loading into Mesoporous Silica Nanoparticles using Co- Spray Drying : a Multi-Scale Study. Microporous and Mesoporous Materials, 2020, 29, ⟨10.1016/j.micromeso.2019.109689⟩. ⟨hal-02378347⟩