Alkylation of manganese(ii) tetraphenylporphyrin by a synthetic antimalarial trioxane

Jean-François Berrien (1) , Olivier Provot (1) , Joëlle Mayrargue (1) , Michel Coquillay (2) , Liliane Cicéron (3) , Frederick Gay (4) , Martin Danis (4) , Anne Robert (5) , B. Meunier (5)

1 BioCIS - Biomolécules : Conception, Isolement, Synthèse
2 Faculté de Pharmacie
3 CIMI - Centre d'Immunologie et de Maladies Infectieuses
4 Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires
5 LCC - Laboratoire de chimie de coordination

The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model Mn II TPP by the biologically active (IC 50 = 320 nmolL-1) hemiperketal 2 is presented.

Domaines: Chimie thérapeutique; Chimie organique

Jean-François Berrien, Olivier Provot, Joëlle Mayrargue, Michel Coquillay, Liliane Cicéron, et al.. Alkylation of manganese(ii) tetraphenylporphyrin by a synthetic antimalarial trioxane. Organic & Biomolecular Chemistry, 2003, 1 (16), pp.2859. ⟨10.1039/b302835f⟩. ⟨hal-02394634⟩