Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae)

Nadja Cachet (1) , Franciane Ho-A-Kwie (1) , Marion Rivaud (1) , Emeline Houël (2) , Eric Deharo (1) , Geneviève Bourdy (1) , Valérie Jullian (1)

1 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
2 UMR ECOFOG - Ecologie des forêts de Guyane

A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC50 = 8 μM), and a similar low activity on human cancerous cells line (IC50 = 7 μM on MCF-7 cells line).

Mots clés: Quassia amara; Simaroubaceae; Quassinoids; Malaria; P. falciparum

Domaines: Chimie analytique

Nadja Cachet, Franciane Ho-A-Kwie, Marion Rivaud, Emeline Houël, Eric Deharo, et al.. Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae). Phytochemistry Letters, 2012, 5 (1), pp.162-164. ⟨10.1016/j.phytol.2011.12.001⟩. ⟨hal-02395428⟩