Hydroxyapatite functionalization to trigger adsorption and release of risedronate

Lucia Forte (1) , Stéphanie Sarda (2) , Christèle Combes (2) , Fabien Brouillet (2) , Massimo Gazzano (3) , Olivier Marsan (2) , Elisa Boanini (1) , Adriana Bigi (1)

1 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
2 CIRIMAT - Centre interuniversitaire de recherche et d'ingenierie des matériaux
3 CNR - National Research Council of Italy | Consiglio Nazionale delle Ricerche

Bisphosphonates are widely employed drugs for the treatment of pathologies characterized by excessive bone resorption, and display a great affinity for apatitic supports. In this work we investigate how hydroxyapatite functionalization can influence the processes of adsorption and release of a bisphosphonate, namely risedronate. To this aim, pure hydroxyapatite (HA), hydroxyapatite with a partial substitution of Zn to Ca (ZnHA) and poly-ethylenimine-functionalized hydroxyapatite (HAPEI) were submitted to interaction with risedronate solution. The results indicate that the mechanisms of adsorption and release are greatly influenced by the type of the apatitic support. All the apatitic supports display Langmuir isotherms for risedronate adsorption. However in the case of HAPEI the plateau is not reached even at high equilibrium concentrations in solution. The data suggest that risedronate adsorption on HAPEI mineral-organic support occurs not only through chemisorption on apatitic phase, as on HA and ZnHA, but also through physisorption involved by PEI coating, which modulates also bisphosphonate release. These properties of tailor-made hydroxyapatite supports could be exploited to develop delivery systems for antiresorptive agents directly on osteoporotic sites.

Mots clés: isphosphonate; Risedronate; Hydroxyapatite; Poly-ethylenimine; Zinc; Adsorption; Release

Domaines: Matériaux; Matériaux

Lucia Forte, Stéphanie Sarda, Christèle Combes, Fabien Brouillet, Massimo Gazzano, et al.. Hydroxyapatite functionalization to trigger adsorption and release of risedronate. Colloids and Surfaces B: Biointerfaces, 2017, 160, pp.493-499. ⟨10.1016/j.colsurfb.2017.09.055⟩. ⟨hal-02400142⟩