Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air® App

Annabelle Bédard (1, 2, 3) , Josep M. Antó (1, 2, 3, 4) , Joao A. Fonseca (5) , Sylvie Arnavielhe (6) , Claus Bachert (7) , Anna Bedbrook (8) , Carsten Bindslev-Jensen (9) , Sinthia Bosnic-Anticevich (10) , Victoria Cardona (11) , Alvaro A. Cruz (12) , Wytske J. Fokkens (13) , Judith Garcia-Aymerich (2, 1, 3) , Peter W. Hellings (14) , Juan C. Ivancevich , Ludger Klimek (15) , Piotr Kuna (16) , Violeta Kvedariene (17) , Désirée Larenas-Linnemann (18) , Erik Melén (19) , Ricardo Monti , Ralf Mösges , Joaquim Mullol (20) , Nikos G. Papadopoulos , Nhân Pham-Thi (21, 22) , Boleslaw Samolinski (23) , Peter V. Tomazic , Sanna Toppila-Salmi , Maria Teresa Ventura , Arzu Yorgancioglu (24) , Jean Bousquet (7, 25, 26) , Oliver Pfaar (27) , Xavier Basagana (28) , The Mask Study Group Jr , I. Agache (29) , Ca Akdis , M. Akdis (30) , Mr Aliberti , R. Almeida (31) , F. Amat (32) , R Angles , I Annesi‐maesano , Ij Ansotegui , Jm Anto (28) , S Arnavielle , E Asayag , A Asarnoj , H Arshad , F Avolio , E Bacci , I Baiardini , C Barbara , M. Barbagallo (33) , I Baroni , Ba Barreto , X. Basagaña (4) , Ed Bateman , M Bedolla‐barajas , M. Bewick (34) , B. Beghé (35) , Eh Bel , Kc Bergmann , Ks Bennoor , M Benson , L Bertorello , Az Białoszewski , T. Bieber , S Bialek , Carsten Bindslev‐jensen , L. Bjermer (36) , H. Blain (25) , F. Blasi (37) , A Blua , M Bochenska Marciniak , I Bogus‐buczynska , Al Boner , M. Bonini (38) , S. Bonini (39) , Cs Bosnic‐anticevich , I. Bosse (40) , J. Bouchard (41) , Lp Boulet , R. Bourret (25) , Pj Bousquet , F Braido , V Briedis , Ce Brightling , J Brozek , C Bucca , R Buhl , R Buonaiuto , C Panaitescu , Mt Burguete Cabañas , E. Burte (26) , A Bush , F Caballero‐fonseca , D. Caillaud (42) , D. Caimmi (43) , Ma Calderon , Pam Camargos , T. Camuzat (44) , G Canfora , Gw Canonica , Kh Carlsen , P Carreiro‐martins , Am Carriazo , W Carr , C. Cartier , T. Casale (45) , G Castellano , L Cecchi , Am Cepeda , Nh Chavannes , Y. Chen (46) , R. Chiron (47) , T Chivato , E Chkhartishvili , Ag Chuchalin , Kf Chung , Mm Ciaravolo , A Ciceran , C Cingi , G Ciprandi , Ac Carvalho Coehlo , L Colas , E Colgan , J Coll , D Conforti , J Constantinidis , J Correia de Sousa , Rm Cortés‐grimaldo , F Corti , E Costa , Mc Costa‐dominguez , Anne-Lise Courbis (48) , L Cox , M Crescenzo , Aa Cruz , A. Custovic (49) , W. Czarlewski (50) , Se Dahlen , G D’amato , C Dario , J. da Silva , Y. Dauvilliers (25) , U Darsow , F. de Blay (51) , G de Carlo , T Dedeu , M de Fátima Emerson , G. de Feo (52) , G de Vries , B de Martino , Np Motta Rubini , D Deleanu , Ja Denburg , P. Devillier (53) , S Di Capua Ercolano , N Di Carluccio , A. Didier (54) , D Dokic , Mg Dominguez‐silva , H Douagui , Gérard Dray (55) , R Dubakiene , Sr Durham , G Du Toit , Ms Dykewicz , Y El‐gamal , P Eklund , E Eller , R. Emuzyte (17) , J Farrell , A Farsi , J Ferreira de Mello , J Ferrero , A Fink‐wagner , A Fiocchi , Wj Fokkens , Ja Fonseca , Jf Fontaine (56) , S Forti , Jm Fuentes‐perez , Jl Gálvez‐romero , A Gamkrelidze , Judith Garcia‐aymerich , Cy García‐cobas , Mh Garcia‐cruz , B Gemicioğlu , S Genova , G Christoff , Je Gereda , R Gerth van Wijk , Rm Gomez , J Gómez‐vera , S González Diaz , M. Gotua (57) , I Grisle , M Guidacci , Na Guldemond , Z Gutter , Ma Guzmán , T. Haahtela (58) , J Hajjam , L Hernández , Jo’b Hourihane , Yr Huerta‐villalobos , M. Humbert , G. Iaccarino (59) , M Illario , Z Ispayeva , Jc Ivancevich , Ej Jares , E Jassem , Sl Johnston , G Joos , Ks Jung , J. Just (60) , M Jutel , I Kaidashev , O Kalayci , Af Kalyoncu , J Karjalainen , P Kardas , T Keil , Pk Keith , M Khaitov , N Khaltaev , J Kleine‐tebbe , Ml Kowalski , M Kuitunen , I. Kull (61) , M Kupczyk , E Krzych‐fałta , P Lacwik , Désirée Larenas‐linnemann , D. Laune (62) , D Lauri , J Lavrut , Ltt Le , M Lessa , G Levato , J. Li (63) , P Lieberman , A Lipiec , B Lipworth , Kc Lodrup Carlsen , R Louis , O Lourenço , Ja Luna‐pech , A. Magnan (64) , B Mahboub , D. Maier (65) , A Mair , I Majer , J Malva , E Mandajieva , P Manning , E de Manuel Keenoy , Gd Marshall , Mr Masjedi , Jf Maspero , E Mathieu‐dupas , Jj Matta Campos , Al Matos , M Maurer , S Mavale‐manuel , O Mayora , C Meco , Ma Medina‐avalos , E Melo‐gomes , Eo Meltzer , E. Menditto (66) , N Miculinic , F. Mihaltan (67) , B Milenkovic , G Moda , Md Mogica‐martinez , Y Mohammad , I. Momas (68) , S Montefort , D Mora Bogado , M Morais‐almeida , Ff Morato‐castro , A Mota‐pinto , P Moura Santo , L Münter , A Muraro , R Murray , R. N Naclerio (69) , R. Nadif (26) , M Nalin , L Napoli , L Namazova‐baranova , H Neffen , V Niedeberger , K Nekam , A Neou , A Nieto , L Nogueira‐silva , M. Nogues (70) , E Novellino , Td Nyembue , Re O’hehir , C Odzhakova , K. Ohta (71) , Y. Okamoto (72) , K Okubo , Gl Onorato , M Ortega Cisneros , S. Ouédraogo , I Pali‐schöll , S Palkonen , P Panzner , Ng Papadopoulos , Hs Park , A. Papi (73) , G Passalacqua , E Paulino , R Pawankar , S Pedersen , Jl Pépin , Am Pereira , M Persico , J Phillips , R. Picard (74) , B Pigearias , I. Pin (75) , C. Pitsios (76) , D Plavec , W Pohl , Ta Popov , F. Portejoie (8) , P Potter , Ac Pozzi , D Price , Ep Prokopakis , R Puy , B Pugin , Re Pulido Ross , M Przemecka , Kf Rabe , F Raciborski , R Rajabian‐soderlund , S Reitsma , I Ribeirinho , J Rimmer , D Rivero‐yeverino , Ja Rizzo , Mc Rizzo , C Robalo‐cordeiro , F Rodenas , X Rodo , M Rodriguez Gonzalez , L Rodriguez‐mañas , C Rolland , S Rodrigues Valle , M. Roman Rodriguez (77) , A Romano , E Rodriguez‐zagal , G Rolla , Re Roller‐wirnsberger , M Romano , J Rosado‐pinto , N. Rosario , M Rottem , D Ryan , H Sagara , J Salimäki , M Sanchez‐borges , J Sastre‐dominguez , Gk Scadding , Hj Schunemann , N Scichilone , P Schmid‐grendelmeier , F Sarquis Serpa , S. Shamai (78) , A. Sheikh (79) , M Sierra , Fer Simons , V. Siroux (80) , Jc Sisul , I Skrindo , D Solé , D Somekh , M Sondermann , T Sooronbaev , M Sova , M Sorensen , M Sorlini , O Spranger , C Stellato , R Stelmach , R Stukas , J. Sunyer (28) , J Strozek , A Szylling , Jn Tebyriçá , M. Thibaudon (81) , T. To , A Todo‐bom , Pv Tomazic , Sanna Toppila‐salmi , U Trama , M Triggiani , C Suppli Ulrik , M Urrutia‐pereira , R Valenta , A. Valero (82) , A. Valiulis (17) , E. Valovirta (83) , M van Eerd , E. van Ganse (84) , M van Hage , O Vandenplas , Mt Ventura , G Vezzani , T Vasankari , A. Vatrella (52) , Mt Verissimo , F. Viart (85) , G. Viegi (86) , D Vicheva , T Vontetsianos , M Wagenmann , S Walker , D Wallace , Dy Wang , S. Waserman (87) , T Werfel , M Westman , M. Wickman (88) , Dm Williams , S Williams , N Wilson , J Wright , P Wroczynski , P Yakovliev , Bp Yawn , Pk Yiallouros , Om Yusuf , Hj Zar , L. Zhang (89) , N Zhong , Me Zernotti , I Zhanat , M Zidarn , T. Zuberbier (90) , C Zubrinich , A Zurkuhlen , Jacques Mercier (91, 25)

1 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
4 IMIM-Hospital del Mar
5 CINTESIS - Center of Research in Health Technologies and Information Systems
6 KYomed INNOV
7 Ghent University Hospital
8 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
9 Odense University Hospital [Odense, Denmark]
10 Woolcock Institute of Medical Research [Sydney]
11 Vall d'Hebron University Hospital [Barcelona]
12 ProAR - FMB
13 EUFOREA - European Forum for Research and Education in Allergy and Airway Diseases
14 University Hospitals Leuven [Leuven]
15 Zentrum für Rhinologie und Allergologie [Wiesbaden, Germany]
16 Division of Internal Medicine, Asthma and Allergy
17 Vilnius University [Vilnius]
18 Clínica de Alergia- Asma y Pediatría
19 Institute of Environmental Medicine
20 CIBERES - Centro de Investigación Biomédica en Red Enfermedades Respiratorias
21 Service de Pneumologie Allergologie [CHU Necker]
22 IP - Institut Pasteur [Paris]
23 Medical University of Warsaw - Poland
24 Department of Pulmonology
25 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
26 VIMA - Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique
27 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
28 CREAL - Center for Research in Environmental Epidemiology
29 Department of Allergy and Clinical Immunology
30 SIAF - Swiss Institute of Allergy and Asthma Research
31 ICEMS - Department Engineering Quimica
32 AMU - Aix Marseille Université
33 INFN, sezione di Bari - Istituto Nazionale di Fisica Nucleare, sezione di Bari
34 iQ4U consultants Ltd
35 Divisions of Human Genetics Infection, Inflammation and Repair
36 Department of Respiratory Medicine and Allergy,
37 Department of Pathophysiology and Transplantation
38 Istituto di Geoscienze e Georisorse, Pavia
39 Institute of Neurobiology and Molecular Medicine
40 CHU Montpellier
41 LNHB (CEA, LIST) - Laboratoire National Henri Becquerel (CEA, LIST)
42 UNH - Unité de Nutrition Humaine
43 LOBIP - Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique
44 Région Languedoc-Roussillon-Midi-Pyrénées
45 USF - University of South Florida [Tampa]
46 Chinese academy of sciences Sanya
47 CRCM [Montpellier] - Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier]
48 LGI2P - Laboratoire de Génie Informatique et d'Ingénierie de Production
49 Department of Paediatrics,
50 UCB Pharma, Colombes
51 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
52 UNISA - Università degli Studi di Salerno = University of Salerno
53 Hôpital Foch [Suresnes]
54 Service de pneumologie [Toulouse]
55 I3A - Informatique, Image, Intelligence Artificielle
56 Le2i - Laboratoire Electronique, Informatique et Image [UMR6306]
57 Center for Allergy and Immunology Research [Tbilisi]
58 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
59 CTR - Center for Turbulence Research [Stanford]
60 CHU Trousseau [APHP]
61 IMM - The Institute of Environmental Medicine [Stockholm]
62 SysDiag - Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic
63 ERTIM - Équipe de Recherche en Textes, Informatique, Multilinguisme
64 ITX - ITX - unité de recherche de l'institut du thorax
65 Biomax Informatics AG
66 "Federico II" University of Naples Medical School
67 Pneumology Department
68 EA 4064 - Epidémiologie Environnementale : Impact Sanitaire des Pollutions
69 Johns Hopkins University School of Medicine [Baltimore]
70 CARSAT-LR, Montpellier,
71 Dept. of Electronic Engineering
72 Institute for Solid State Physics
73 Respiratory Medicine,
74 LPCNO - Laboratoire de physique et chimie des nano-objets
75 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
76 UCY - University of Cyprus [Nicosia]
77 Son Pisa Primary Care Centre
78 Department of Computer Science [Haifa]
79 Edin. - University of Edinburgh
80 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
81 RNSA - Réseau National de Surveillance Aérobiologique
82 CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain
83 University of Turku
84 Evaluation et modélisation des effets thérapeutiques
85 ASA (Advanced Solution Accelerator) (Data management : Développement Back-Office, hébergement…), 34830 Jacou
86 Consiglio nazionale delle ricerche
87 McMaster University [Hamilton, Ontario]
88 Department of Molecular Medicine and Surgery
89 UMR CNRS 8179
90 University Hospital of Cologne [Cologne]
91 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]

Background: In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK‐air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom‐medication scores obtained concurrently. Methods: All consecutive MASK‐air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self‐assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom‐medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra‐individual response variability (IRV) index was calculated. Results: A strong correlation was observed between VAS work and other VAS. The highest levels for correlation with VAS work and variance explained in VAS work were found with VAS global, followed by VAS nose, eye and asthma. In comparison with VAS global, the mCSMS and MASK control score showed a lower correlation with VAS work. Results are unlikely to be explained by a low quality of data arising from repeated VAS measures. Conclusions: VAS work correlates with other outcomes (VAS global, nose, eye and asthma) but less well with a symptom‐medication score. VAS work should be considered as a potentially useful AR outcome in intervention studies.

Mots clés: asthma; MASK; rhinitis; score; visual analogue scale

Domaines: Médecine humaine et pathologie; Immunologie

Annabelle Bédard, Josep M. Antó, Joao A. Fonseca, Sylvie Arnavielhe, Claus Bachert, et al.. Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air® App. Allergy, 2020, 75 (7), pp.1672-1688. ⟨10.1111/all.14204⟩. ⟨hal-02462027⟩