Rhodium(III)-Catalyzed [4+3] Annulation of N -Aryl-pyrazolidinones and Propargylic Acetates: Access to Benzo[ c ][1,2]diazepines

Tingfang Li (1) , Zi Yang (1) , Zhenyu Song (1) , Rémi Chauvin (2, 1) , Xiuling Cui (1)

1 HQU - Huaqiao University
2 LCC - Laboratoire de chimie de coordination

The generation of 2,3-dihydro-benzo[c][1,2]diazepine derivatives via rhodium(III)-catalyzed [4+3] annulation of pyrazolidinones and propargylic acetates is disclosed. The reaction proceeds smoothly under relatively mild conditions from propargylic acetates as novel C3 synthons. A range of dinitrogen-fused heterocyclic compounds are readily accessed by this approach.

Domaines: Chimie de coordination

Tingfang Li, Zi Yang, Zhenyu Song, Rémi Chauvin, Xiuling Cui. Rhodium(III)-Catalyzed [4+3] Annulation of N -Aryl-pyrazolidinones and Propargylic Acetates: Access to Benzo[ c ][1,2]diazepines. Organic Letters, 2020, 22 (11), pp.4078-4082. ⟨10.1021/acs.orglett.0c01139⟩. ⟨hal-02613327⟩