On quantitative trait locus mapping with an interference phenomenon

Charles-Elie Rabier (1, 2, 3)

1 SAGA - Station d'Amélioration Génétique des Animaux
2 UT3 - Université Toulouse III - Paul Sabatier
3 University of Wisconsin-Madison

We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL (a QTL denotes a gene with quantitative effect on a trait) on the interval [0, T] representing a chromosome. The observation is the trait and the composition of the genome at some locations called "markers". We focus on the interference phenomenon, i.e. a recombination event inhibits the formation of another recombination event nearby. We give the asymptotic distribution of the LRT process under the null hypothesis that there is no QTL on [0, T] and under local alternatives with a QTL at on [0, T]. We show that the LRT process is asymptotically the square of a "linear interpolated and normalized process". We prove that under the null hypothesis, the distribution of the maximum of the LRT process is the same for a model with or without interference. However, the powers of detection are totally different between the two models.

Mots clés: Likelihood ratio test; Chi-square process

Mots clés: Quantitative trait locus detection; Gaussian process

Domaines: Sciences du Vivant [q-bio]

Charles-Elie Rabier. On quantitative trait locus mapping with an interference phenomenon. Test, 2014, 23 (2), pp.311-329. ⟨10.1007/s11749-013-0349-z⟩. ⟨hal-02632505⟩