Effect of phosphorus dendrimers on DMPC lipid membranes

Maksim Ionov (1) , Dominika Wróbel (1) , Konstantinos Gardikis (2) , Sophia Hatziantoniou (2) , Costas Demetzos (2) , Jean Pierre Majoral (3) , Barbara Klajnert (1) , Maria Bryszewska (1)

1 Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz
2 NKUA - National and Kapodistrian University of Athens
3 LCC - Laboratoire de chimie de coordination

Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G3 and G4. DSC and ζ-potential measurements have shown that liposomal-dendrimeric molecular recognition probably occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids that interact with CPDs is dependent on the dendrimers generation. These results can be used in order to rationally design mixed modulatory liposomal locked-in dendrimeric, drug delivery nano systems.

Mots clés: Phosphorus dendrimers; DMPC; DSC; ζ-Size/potential

Domaines: Chimie de coordination

Maksim Ionov, Dominika Wróbel, Konstantinos Gardikis, Sophia Hatziantoniou, Costas Demetzos, et al.. Effect of phosphorus dendrimers on DMPC lipid membranes. Chemistry and Physics of Lipids, 2012, 165 (4), pp.408-413. ⟨10.1016/j.chemphyslip.2011.11.014⟩. ⟨hal-02909948⟩