Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

Cathy Danesin (1) , Romain Darche-Gabinaud , Nathalie Escalas (1) , Vanessa Bouguetoch , Philippe Cochard , Amir Al Oustah , David Ohayon (1) , Bruno Glise , Cathy Soula

1 CBI - Centre de Biologie Intégrative

Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates, a critical regulation level for their role in modulating the activity of signalling molecules. Data presented here define Sulf2a as a novel player in the control of Sonic Hedgehog (Shh)mediated cell type specification during spinal cord development. We show that Sulf2a depletion in

Mots clés: Gliogenesis; Zebrafish; Extracellular sulfatase; Sulfatase 2; Sonic hedgehog; Neurogenesis

Domaines: Sciences du Vivant [q-bio]

Cathy Danesin, Romain Darche-Gabinaud, Nathalie Escalas, Vanessa Bouguetoch, Philippe Cochard, et al.. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. 2020. ⟨hal-03018910⟩