Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

James Meixiong (1) , Lilian Basso (2) , Xinzhong Dong (1) , Nicolas Gaudenzio (2)

1 JHU - Johns Hopkins University
2 UDEAR - Unité différenciation épidermique et auto-immunité rhumatoïde

Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.

Mots clés: Nociceptive sensory neuron; substance P; mast cell; MrgprB2/X2; skin

Domaines: Maladies infectieuses

James Meixiong, Lilian Basso, Xinzhong Dong, Nicolas Gaudenzio. Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis. Trends in Neurosciences, 2020, 43 (3), pp.130-132. ⟨10.1016/j.tins.2020.01.001⟩. ⟨hal-03152151⟩