Incidence and risk factors for dupilumab associated ocular adverse events
Résumé
Background : Dupilumab is approved for use in moderate-to-severe atopic dermatitis (AD) and as an add-on maintenancetreatment in patients suffering from severe asthma with type 2 inflammation. Ocular adverse events (OAEs) havebeen reported with dupilumab almost exclusively in patients treated for AD. Objectives : The objectives of this study were to describe the incidence and nature of dupilumab-induced OAEs and toassess the potential predisposing factors. Patients and methods We conducted a prospective, single-centre, real-life study in adult AD patients treated with dupilumab, who were systematically examined by an ophthalmologist before and during treatment. Results : Forty-six patients were included prospectively with a median age of 41.1 years and a median initial SCOring Atopic Dermatitis of 46.0 (IQR: 34.5–55.5). OAEs concerned 34.8% of patients and were mostly of mild to moderate severity. Two patients had to discontinue treatment due to OAE. The majority of patients developed or aggravated dry eye disease, with superficial punctate keratitis (SPK). Six patients developed conjunctivitis. Dupilumab-induced OAEs,were associated with the following pre-existing parameters: dry eye disease with SPK (Odds ratio (OR); 6.3 [95% confidence interval (CI): 1.3–31.6]), eyelid eczema (OR: 8.7 [95%CI:1.8–40.6]), history of food allergy (OR 3.8 (95% CI: 1.002– 14,070) and IgE serum level> 1000 kU/L (OR:10.6 [CI 95%: 1.2–91.3]).
Conclusion : Atopic dermatitis patients with eyelid eczema or dry eye disease symptoms may be referred to an ophthalmologist before starting dupilumab to consider initiating preventive eye hydration measures. Further multicentric and translational studies are warranted to better explain OAEs pathophysiology.