Deimination, Intermediate Filaments and Associated Proteins

Julie Briot (1) , Michel Simon (1) , Marie-Claire Méchin (1)

1 UDEAR - Unité différenciation épidermique et auto-immunité rhumatoïde

Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes.

Mots clés: citrullination; cytoskeleton; filaggrin; keratin; peptidylarginine deiminase; post-translational modification

Domaines: Maladies infectieuses

Julie Briot, Michel Simon, Marie-Claire Méchin. Deimination, Intermediate Filaments and Associated Proteins. International Journal of Molecular Sciences, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩. ⟨hal-03287044⟩