Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol.

Vanessa Faugeroux (1) , Yves Génisson (1) , Yahya Salma (1) , Patricia Constant (2) , Michel Baltas (1)

1 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique
2 IPBS - Institut de pharmacologie et de biologie structurale

Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.

Vanessa Faugeroux, Yves Génisson, Yahya Salma, Patricia Constant, Michel Baltas. Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol.. Bioorganic and Medicinal Chemistry, 2007, 15 (17), pp.5866-76. ⟨10.1016/j.bmc.2007.05.064⟩. ⟨inserm-00409609⟩