Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.

D. L. A. Rakotondramanana (1) , Mélanie Delomenède (1) , Michel Baltas (1) , Hubert Duran (1) , Florence Bedos-Belval (1) , Philippe Rasoanaivo (2) , Anne Nègre-Salvayre (3) , Heinz Gornitzka (4)

1 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique
2 Laboratoire de Pharmacognosie Appliquée aux Maladies Infectieuses et Parasitaires
3 Régulations cellulaires: lipidoses et atherosclerose
4 LHFA - Laboratoire Hétérochimie Fondamentale et Appliquée

Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.

Domaines: Chimie

D. L. A. Rakotondramanana, Mélanie Delomenède, Michel Baltas, Hubert Duran, Florence Bedos-Belval, et al.. Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.. Bioorganic and Medicinal Chemistry, 2007, 15 (18), pp.6018-26. ⟨10.1016/j.bmc.2007.06.047⟩. ⟨inserm-00409724⟩