Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion.

Julie Favre (1, 2) , Ji Gao (1) , Jean-Paul Henry (1) , Isabelle Remy-Jouet (1) , Isabelle Fourquaux (3) , Audrey Billon-Gales (2) , Christian Thuillez (1) , Jean-François Arnal (2) , Françoise Lenfant (2) , Vincent Richard (1)

1 Pharmacologie des Dysfonctionnements Endotheliaux et Myocardiques
2 I2MR - Institut de médecine moléculaire de Rangueil
3 CMEAB - Centre de Microscopie Électronique Appliquée à la Biologie

Endothelial ERα plays a crucial role in the E2-induced prevention of endothelial dysfunction after I/R. To our knowledge, we demonstrate for the first time, by using unique genetically modified mice, that targeting endothelial protection per se can confer cardiomyocyte protection in I/R.

Julie Favre, Ji Gao, Jean-Paul Henry, Isabelle Remy-Jouet, Isabelle Fourquaux, et al.. Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion.. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 30 (12), pp.2562-7. ⟨10.1161/ATVBAHA.110.213637⟩. ⟨inserm-00550876⟩