Pathological aspects of lipid peroxidation.
Anne Negre-Salvayre
(1)
,
Nathalie Auge
(1)
,
Victoria Ayala
(2)
,
Huveyda Basaga
(3)
,
Jordi Boada
(2)
,
Rainer Brenke
(4)
,
Sarah Chapple
(5)
,
Guy Cohen
(6)
,
Janos Feher
(7)
,
Tilman Grune
(8)
,
Gabriella Lengyel
(7)
,
Giovanni E. Mann
(5)
,
Reinald Pamplona
(2)
,
Giuseppe Poli
(9)
,
Manuel Portero-Otin
(2)
,
Yael Riahi
(6)
,
Robert Salvayre
(1)
,
Shlomo Sasson
(6)
,
Jose Serrano
(2)
,
Ofer Shamni
(6)
,
Werner Siems
(10)
,
Richard C. M. Siow
(5)
,
Ingrid Wiswedel
(11)
,
Kamelija Zarkovic
(12)
,
Neven Zarkovic
(13)
1
I2MR -
Institut de médecine moléculaire de Rangueil
2 Departament de Medicina Experimental
3 Biological Sciences and Bioengineering Program
4 Hufeland Hospital
5 Cardiovascular Division
6 Department of Pharmacology
7 2nd Department of Medicine
8 Institute of Biological Chemistry and Nutrition
9 Department of Clinical and Biological Sciences
10 Research Institute of Physiotherapy and Gerontology
11 Department of Pathological Biochemistry
12 Department of Neuropathology
13 Rudjer Boskovic Institute [Zagreb]
2 Departament de Medicina Experimental
3 Biological Sciences and Bioengineering Program
4 Hufeland Hospital
5 Cardiovascular Division
6 Department of Pharmacology
7 2nd Department of Medicine
8 Institute of Biological Chemistry and Nutrition
9 Department of Clinical and Biological Sciences
10 Research Institute of Physiotherapy and Gerontology
11 Department of Pathological Biochemistry
12 Department of Neuropathology
13 Rudjer Boskovic Institute [Zagreb]
Anne Negre-Salvayre
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Résumé
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.