ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.

Santiago Zalvidea (1) , Lucas Andre (1) , Xavier Loyer (2) , Cécile Cassan (1) , Yannis Sainte-Marie (3) , Jérôme Thireau (1) , Ivar Sjaastad (4) , Christophe Heymes (3) , Jean Luc Pasquié (1, 5) , Olivier Cazorla (1) , Franck Aimond (1) , Sylvain Richard (1)

1 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
2 PARCC - UMR-S U970 - Paris-Centre de Recherche Cardiovasculaire
3 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
4 Institute for Experimental Medical Research
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

Mots clés: hypertrophy; excitation-contraction coupling; sarcoplasmic reticulum Ca2+ ATPase; myofilaments; sarcoplasmic reticulum Ca2+ ATPase.; Angiotensin-converting enzyme inhibitors; heart failure

Domaines: Cardiologie et système cardiovasculaire

Santiago Zalvidea, Lucas Andre, Xavier Loyer, Cécile Cassan, Yannis Sainte-Marie, et al.. ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.: Molecular effects of delapril on cardiomyocytes.. Current Molecular Medicine, 2012, 12 (2), pp.206-17. ⟨10.2174/156652412798889045⟩. ⟨inserm-00665476⟩