Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.

Renaud Dentin (1) , Dominique Langin (2, 3, 4) , Catherine Postic (1)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
3 UT3 - Université Toulouse III - Paul Sabatier
4 Laboratoire de Biochimie [CHU Toulouse]

The ChREBP transcription factor is regulated by glucose and plays a role in insulin sensitivity, but the mechanism underlying these effects remains unclear. In a recent Nature article, Herman et al. (2012) show that a shorter ChREBP isoform (ChREBP-β) links glucose transport to lipogenesis in white adipose tissue.

Domaines: Endocrinologie et métabolisme

Renaud Dentin, Dominique Langin, Catherine Postic. Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.. Cell Metab, 2012, 15 (6), pp.795-7. ⟨10.1016/j.cmet.2012.05.007⟩. ⟨inserm-00726503⟩