Dendrimers ended by non-symmetrical azadiphosphonate groups: Synthesis and immunological properties

Patrice Marchand (1) , Laurent Griffe (1) , Mary Poupot (2, 3) , Cédric-Olivier Turrin (1) , Gérard Bacquet (4) , Jean-Jacques Fournié (2, 3) , Jean Pierre Majoral (1) , Rémy Poupot (2, 3) , Anne-Marie Caminade (1)

1 LCC - Laboratoire de chimie de coordination
2 INSERM U563 - CNRS UMR1037 - Centre de Physiopathologie de Toulouse-Purpan
3 UT3 - Université Toulouse III - Paul Sabatier
4 RHODIA - Centre de Recherches d'Aubervilliers

The synthesis and characterization of new series of phosphorus-containing dendrimers ended by non-symmetrical azamonophosphonates, or azadiphosphonates, or azadiphosphonic acid salts are reported. The sodium salts of the non-symmetrical azadiphosphonic dendrimers are soluble in water. Their influence towards human immune blood cells is assayed ex vivo.

Domaines: Hématologie

Patrice Marchand, Laurent Griffe, Mary Poupot, Cédric-Olivier Turrin, Gérard Bacquet, et al.. Dendrimers ended by non-symmetrical azadiphosphonate groups: Synthesis and immunological properties. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (14), pp.3963-3966. ⟨10.1016/j.bmcl.2009.03.003⟩. ⟨inserm-02472251⟩