The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample

Indrit Bègue , Yannis Elandaloussi (1, 2) , Farnaz Delavari (3) , Hengyi Cao , Alexandra Moussa-Tooks , Mathilde Roser (1, 2) , Pierrick Coupé (4) , Marion Leboyer (1) , Stefan Kaiser (3) , Josselin Houenou (1, 2) , Roscoe Brady , Charles Laidi (1, 2)

1 IMRB - Institut Mondor de Recherche Biomédicale
2 UNIACT - Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle
3 UNIGE - Université de Genève = University of Geneva
4 PICTURA - Patch-based processing for medical and natural images

Multiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check ( n = 662 subjects retained from initial n = 1452). Canonical correlation analyses (CCA) examined regional gray matter volumetric (GMV) differences in association to cognitive function (quantified with NIH Toolbox Cognition domain, NIH-TB), accounting for psychopathology severity, age, sex, scan location, and intracranial volume. Multivariate CCA uncovered a significant correlation between two components entailing a latent cognitive canonical (NIH-TB subscales) and a brain canonical variate (cerebellar GMV and intracranial volume, ICV), surviving bootstrapping and permutation procedures. The components correspond to partly shared cerebellar-cognitive function relationship with a first map encompassing cognitive flexibility ( r = 0.89), speed of processing ( r = 0.65), and working memory ( r = 0.52) associated with regional GMV in crus II ( r = 0.57) and lobule X ( r = 0.59) and a second map including the crus I ( r = 0.49) and lobule VI ( r = 0.49) associated with working memory ( r = 0.51). We show evidence for a structural subspecialization of the cerebellum topography for cognitive function in a transdiagnostic sample.

Mots clés: Cerebellum Cognition Cognitive flexibility Healthy Brain Network Structural neuroimaging; Cerebellum; Cognition; Cognitive flexibility; Healthy Brain Network; Structural neuroimaging

Domaines: Sciences cognitives

Indrit Bègue, Yannis Elandaloussi, Farnaz Delavari, Hengyi Cao, Alexandra Moussa-Tooks, et al.. The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample. The Cerebellum, In press, ⟨10.1007/s12311-023-01645-y⟩. ⟨hal-04577707⟩