Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors

Maria John , Roberto Salgado (1) , Thomas Gevaert , Prudence A Russell , Tom John , Bibhusal Thapa , Michael Christie , Koen van de Vijver , M V Estrada , Paula I Gonzalez-Ericsson , Melinda Sanders , Benjamin D. Solomon (2) , Cinzia Solinas , Gert G G M van den Eynden , Yves Allory (3) , Matthias Preusser , Johannes Hainfellner , Giancarlo Pruneri (4) , Andre Vingiani , Sandra Demaria , Fraser Symmans , Paolo Nuciforo (5) , Laura Comerma , E A Thompson , Sunil Lakhani , Seong-Rim Kim , Stuart Schnitt , Cecile Colpaert , Christos Sotiriou (1) , Stefan Scherer (6) , Michail Ignatiadis (7) , Sunil Badve , Robert H Pierce , Giuseppe Viale (8) , Nicolas Sirtaine , Fred Penault-Llorca (9, 10) , Tomohagu Sugie , Susan Fineberg , Soonmyung Paik , Ashok Srinivasan , Andre Richardson , Yihong Wang , Ewa Chmielik , Jane Brock , Douglas B Johnson , Justin Balko , Stephan Wienert , Veerle Bossuyt , Stefan Michiels (11) , Nils F Ternès (12) , Nicole Burchardi , Stephen Luen , Peter Savas , Fred Klauschen , Peter H Watson , Brad H Nelson (13) , Carmen Criscitiello , Sandra O'Toole , Denis Larsimont (14) , Roland de Wind , Giuseppe Curigliano (15) , Fabrice André (16) , Magali Lacroix-Triki (17) , Mark van de Vijver , Federico Rojo , Giuseppe Floris , Shahinaz Bedri , Joseph Sparano , David Rimm , Torsten Nielsen , Zuzana Kos , Stephen Hewitt , Baljit Singh , Gelareh Farshid , Sibylle Loi , Kimberly H Allison , Nadine Tung , Sylvia Adams , Karen Willard-Gallo , Hugo M Horlings , Leena Gandhi , Andre Moreira (18) , Fred R. Hirsch (19) , Maria Dieci , Maria Urbanowicz , Iva Brcic , Konstanty Korski , Fabien Gaire , Hartmut Koeppen , Amy Lo , Jennifer Giltnane , Marlon C Rebelatto , Keith E Steele , Jiping Zha , Kenneth Emancipator , Jonathan W Juco , Carsten Denkert (20) , Jorge Reis-Filho (21) , Sherene Loi (1) , Stephen B Fox , Shona Hendry , Prudence A. Russell , M.V. Estrada , Paula I. Gonzalez-Ericsson , Gert G.G.M. van den Eynden , E.A. Thompson , Robert H. Pierce (22) , Douglas B. Johnson (23) , Peter H. Watson , Brad H. Nelson , Sandra O’toole , Kimberly H. Allison , Hugo M. Horlings , Marlon C. Rebelatto , Keith E. Steele , Jonathan W. Juco , Stephen B. Fox (24)

1 Breast Cancer Translational Research Laboratory
2 Cancer Genetics Branch
3 Service d'urologie [Mondor]
4 Division of Pathology and Laboratory Medicine
5 FIRC
6 Trinity College Dublin
7 Department of medical oncology
8 Division of Pathology and Laboratory Medicine
9 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
10 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
11 SBE - Service de biostatistique et d'épidémiologie
12 U1018 (Équipe 2) - Méthodologie et épidémiologie clinique en oncologie moléculaire
13 Trev and Joyce Deeley Research Center
14 Institut Jules Bordet [Bruxelles]
15 Division of Medical Oncology
16 Département de médecine oncologique [Gustave Roussy]
17 Département de Biologie et de Pathologie
18 Department of Dermatology
19 University of Colorado Cancer Center
20 Charité, Institute of Pathology, Translational Tumorpathology Unit
21 Breakthrough Breast Cancer Centre
22 Department of Experimental Pathology & Pharmacology
23 Vanderbilt University School of Medicine [Nashville]
24 Department of Pathology

Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.

Domaines: Cancer

Maria John, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, et al.. Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors. Advances in Anatomic Pathology, 2017, 24 (6), pp.311 - 335. ⟨10.1097/PAP.0000000000000161⟩. ⟨hal-01675236⟩