[Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032].

Jean-Pierre Flandrois (1, 2) , G. Carret (2) , M. Peyret , Catherine Pichat (3)

1 BPGE - Bioinformatique, phylogénie et génomique évolutive
2 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
3 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]

This work has been performed to study the inoculum effect on the in vitro activity of LY 146032, a new lipopeptide antibiotic. A statistical analysis (X2 and t test) of the data concerning the MIC of different bacterial groups has been carried out to appreciate the phenomenon. The activity of vancomycin has been compared. A major inoculum effect has been detected for LY 146032. It must be taken into account to evaluate the activity of this new antibiotic.

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]; Evolution [q-bio.PE]; Systématique, phylogénie et taxonomie; Ecosystèmes; Bactériologie

Jean-Pierre Flandrois, G. Carret, M. Peyret, Catherine Pichat. [Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032].. Pathologie Biologie, 1988, 36 (5), pp.377-80. ⟨hal-02332666⟩