A continuous stochastic maturation model
Résumé
We present a continuous time model of maturation and survival, obtained as the limit of a compartmental evolution model when the number of compartments tends to infinity. We establish in particular an explicit formula for the law of the system output under inhomogeneous killing and when the input follows a time-inhomogeneous Poisson process. Identifiability issues are discussed, and an application to the modelling of the toxicity of anti-cancer drugs is given. Such models can be seen in particular as generalisations of previous works of Jacquez & Simon and Schuhmacher & Thieme.