First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy.

Raphaël Serduc (1, 2, 3) , Elke Bräuer-Krisch (2) , Audrey Bouchet (2) , Luc Renaud (3) , Thierry Brochard (2) , Alberto Bravin (2) , Jean Albert Laissue (4) , Géraldine Le Duc (2)

1 Neuroimagerie Fonctionnelle et Metabolique
2 ESRF - European Synchrotron Radiation Facility
3 CERCO - Centre de recherche cerveau et cognition
4 Institute of Pathology

The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.

Mots clés: synchrotron microbeam radiation therapy; brain tumors; temporal fractionation

Domaines: Neurosciences [q-bio.NC]

Raphaël Serduc, Elke Bräuer-Krisch, Audrey Bouchet, Luc Renaud, Thierry Brochard, et al.. First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy.. Journal of Synchrotron Radiation, 2009, 16 (Pt 4), pp.587-90. ⟨10.1107/S0909049509012485⟩. ⟨hal-00421096⟩