Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent

Yannick Degboé (1, 2) , S. Fruchon (2) , M. Baron (2) , D. Nigon (1, 2) , Cédric-Olivier Turrin (3) , A.-M. Caminade (3) , R. Poupot (2) , A. Cantagrel (1, 2) , J.-L. Davignon (1, 2)

1 Centre de Rhumatologie [CHU Toulouse]
2 CPTP - Centre de Physiopathologie Toulouse Purpan
3 LCC - Laboratoire de chimie de coordination

Our objective was to assess the capacity of dendrimer aza-bis-phosphonate (ABP) to modulate phenotype of monocytes (Mo) and monocytes derived dendritic cells (MoDC) activated in response to toll-like receptor 4 (TLR4) and interferon γ (IFN- γ) stimulation.

Domaines: Chimie de coordination

Yannick Degboé, S. Fruchon, M. Baron, D. Nigon, Cédric-Olivier Turrin, et al.. Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent. Arthritis Research and Therapy, 2014, 16 (2), pp.R98/1-10. ⟨10.1186/ar4546⟩. ⟨hal-02007953⟩