Solid-phase extraction of drugs with cuttlebone powder as a sorbent
Résumé
We investigated cuttlefish bone powder for the solid-phase extraction of naproxen, ibuprofen and carbamazepine. The basic principles controlling the extraction are presented to aid in the choice of the nature and quantity of the extracting phase according to the sample matrix and the solute properties, based on the mechanisms of phase retention. Their retention mechanism is based on hydrogen bonding and electrostatic interactions. The results show a significant recovery rate for the three drugs, selectivity and low cost. The method has successfully reduced the amount of tested pharmaceuticals with recoveries higher than 87% at pH 4.