The Amino-Terminal Part of Human FLG2 Is a Component of Cornified Envelopes

Géraldine Albérola (1) , Jens-Michael Schröder (2) , Carine Froment (3) , Michel Simon (1)

1 UDEAR - Unité différenciation épidermique et auto-immunité rhumatoïde
2 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
3 IPBS - Institut de pharmacologie et de biologie structurale

FLG2, a member of the S100-fused type protein family, is a 250-kDa protein expressed mainly in differentiated keratinocytes of the epidermis (Hsu et al.,2011; Wu et al., 2009). Its expression isreduced in atopic dermatitis (Pellerinet al., 2013), and FLG2 gene heterozygous non-sense mutations are associated with amore persistent formof the disease in African-American populations (Margolis et al., 2014). Loss of FLG2 due to homozygous mutations is responsible for peeling skin syndrome type A (Bolling et al., 2018; Mohamad et al., 2018).

Domaines: Maladies infectieuses

Géraldine Albérola, Jens-Michael Schröder, Carine Froment, Michel Simon. The Amino-Terminal Part of Human FLG2 Is a Component of Cornified Envelopes. Journal of Investigative Dermatology, 2019, 139 (6), pp.1395-1397. ⟨10.1016/j.jid.2018.11.022⟩. ⟨hal-03180678⟩