Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics

Merlin Sanicas (1, 2) , Remy Torro (3) , Laurent Limozin (3) , Patrick Chames (4, 5, 6, 7, 8)

1 IPBS - Institut de pharmacologie et de biologie structurale
2 UCBL - Université Claude Bernard Lyon 1
3 LAI - Adhésion et Inflammation
4 CNRS - Centre National de la Recherche Scientifique
5 INSERM - Institut National de la Santé et de la Recherche Médicale
6 CRCM - Centre de Recherche en Cancérologie de Marseille
7 IPC - Institut Paoli-Calmettes
8 AMU - Aix Marseille Université

In vitro display technologies such as yeast display have been instrumental in developing the selection of new antibodies, antibody fragments or nanobodies that bind to a specific target, with affinity...

Mots clés: electronics; imaging; materials; mechanical components and more Yeast Display; Laminar Flow Chamber; nanobodies; Cell Enrichment

Domaines: Biotechnologies; Sciences du Vivant [q-bio]; Cancer; Immunologie; Immunothérapie

Merlin Sanicas, Remy Torro, Laurent Limozin, Patrick Chames. Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics. Lab on a Chip, 2024, ⟨10.1039/D4LC00011K⟩. ⟨hal-04562911v1⟩